Aclene 0.10% Gel

Manufacturers Cipla Ltd salt_composition Acyclovir (5% w/w) » Prescription Required « Prescription Required In Herpes labialis Herpes labialis, commonly known as cold sores, is a viral infection that primarily affects the lip. Symptoms typically include a burning pain followed by small blisters or sores. Acivir Cream can speed up healing of herpes labialis and also prevent recurrence of the sores. Keep using this medicine as prescribed by the doctor to get maximum benefit. » how_to_use « This medicine is for external use only. Use it in the dose and duration as advised by your doctor. Check the label for directions before use. Clean and dry the affected area and apply the cream. Wash your hands after applying, unless hands are the affected area. » Benefits « This medicine is for external use only. Use it in the dose and duration as advised by your doctor. Check the label for directions before use. Clean and dry the affected area and apply the cream. Wash your hands after applying, unless hands are the affected area. » common_side_effect « Application site reactions (burning, irritation, itching and redness) » If_miss « If you miss a dose of Acivir Cream, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose. » Safety_advise « - Alcohol : None No interaction found/established - Pregnancy : CONSULT YOUR DOCTOR Information regarding the use of Acivir Cream during pregnancy is not available. Please consult your doctor. - Breast feeding : CONSULT YOUR DOCTOR Acivir Cream is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. - Driving : None No interaction found/established - Kidney : None No interaction found/established - Liver : None No interaction found/established

Manufacturers Cipla Ltd salt_composition Calcium Carbonate (80mg) + Sodium Alginate (250mg) + Sodium Bicarbonate (133.5mg) » Prescription Required « Prescription Required In Treatment of Heartburn Heartburn is a burning feeling in your chest caused by stomach acids traveling back up towards your throat and mouth (acid reflux). Algisod Oral Liquid Peppermint improves the movement of food in the stomach and helps prevent heartburn.\u003cbr>\u003cbr>You should take it exactly as it is prescribed or as it says on the label for it to be effective. Some simple lifestyle changes can help stop or reduce heartburn. Think about what foods trigger heartburn and try to avoid them; eat smaller, more frequent meals; try to lose weight if you are overweight and try to find ways to relax. Do not eat within 3 to 4 hours of going to bed. » how_to_use « Take this medicine in the dose and duration as advised by your doctor. Check the label for directions before use. Measure it with measuring cup and take it by mouth. Shake well before use. Algisod Oral Liquid Peppermint may be taken with or without food, but it is better to take it at a fixed time. » Benefits « Take this medicine in the dose and duration as advised by your doctor. Check the label for directions before use. Measure it with measuring cup and take it by mouth. Shake well before use. Algisod Oral Liquid Peppermint may be taken with or without food, but it is better to take it at a fixed time. » common_side_effect « No common side effects seen » If_miss « If you miss a dose of Algisod Oral Liquid Peppermint, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose. » Safety_advise « - Alcohol : CONSULT YOUR DOCTOR It is not known whether it is safe to consume alcohol with Algisod Oral Liquid Peppermint. Please consult your doctor. - Pregnancy : SAFE IF PRESCRIBED Algisod Oral Liquid Peppermint is safe to use during pregnancy. Most studies have shown low or no risk to the developing baby. - Breast feeding : SAFE IF PRESCRIBED Algisod Oral Liquid Peppermint is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby. - Driving : CONSULT YOUR DOCTOR It is not known whether Algisod Oral Liquid Peppermint alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. - Kidney : CONSULT YOUR DOCTOR There is limited information available on the use of Algisod Oral Liquid Peppermint in patients with kidney disease. Please consult your doctor. - Liver : CONSULT YOUR DOCTOR There is limited information available on the use of Algisod Oral Liquid Peppermint in patients with liver disease. Please consult your doctor.

Manufacturers Cipla Ltd salt_composition Calcium Carbonate (80mcg) + Sodium Alginate (250mg) + Sodium Bicarbonate (133.5mg) » Prescription Required « Prescription Required In Treatment of Heartburn Heartburn is a burning feeling in your chest caused by stomach acids traveling back up towards your throat and mouth (acid reflux). Algisod Peppermint Oral Suspension improves the movement of food in the stomach and helps prevent heartburn.\u003cbr>\u003cbr>You should take it exactly as it is prescribed or as it says on the label for it to be effective. Some simple lifestyle changes can help stop or reduce heartburn. Think about what foods trigger heartburn and try to avoid them; eat smaller, more frequent meals; try to lose weight if you are overweight and try to find ways to relax. Do not eat within 3 to 4 hours of going to bed. » how_to_use « Take this medicine in the dose and duration as advised by your doctor. Check the label for directions before use. Measure it with a measuring cup and take it by mouth. Shake well before use. Algisod Peppermint Oral Suspension may be taken with or without food, but it is better to take it at a fixed time. » Benefits « Take this medicine in the dose and duration as advised by your doctor. Check the label for directions before use. Measure it with a measuring cup and take it by mouth. Shake well before use. Algisod Peppermint Oral Suspension may be taken with or without food, but it is better to take it at a fixed time. » common_side_effect « No common side effects seen » If_miss « If you miss a dose of Algisod Peppermint Oral Suspension, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose. » Safety_advise « - Alcohol : CONSULT YOUR DOCTOR It is not known whether it is safe to consume alcohol with Algisod Peppermint Oral Suspension. Please consult your doctor. - Pregnancy : SAFE IF PRESCRIBED Algisod Peppermint Oral Suspension is safe to use during pregnancy. Most studies have shown low or no risk to the developing baby. - Breast feeding : SAFE IF PRESCRIBED Algisod Peppermint Oral Suspension is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby. - Driving : CONSULT YOUR DOCTOR It is not known whether Algisod Peppermint Oral Suspension alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. - Kidney : CONSULT YOUR DOCTOR There is limited information available on the use of Algisod Peppermint Oral Suspension in patients with kidney disease. Please consult your doctor. - Liver : CONSULT YOUR DOCTOR There is limited information available on the use of Algisod Peppermint Oral Suspension in patients with liver disease. Please consult your doctor.

Manufacturers Cipla Ltd salt_composition Nevirapine (200mg) » Prescription Required « Prescription Required In Treatment of HIV infection Nevimune Tablet prevents HIV from multiplying in the body. It helps control the infection and makes the immune system work better. This lowers the chances of getting complications, such as new infections, and improves your quality of life.\u003cbr>\u003cbr>Nevimune Tablet is not a cure for HIV or AIDS and should not be used to prevent HIV after accidental exposure. It is important that this medicine be taken as prescribed by the doctor. Taking all doses in the right amount at the right times greatly increases the effectiveness of the medicine and reduces the chances of HIV infection becoming resistant to antiretroviral medicines. Although taking this medicine will not prevent the passing of HIV to other people. » how_to_use « Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Nevimune Tablet may be taken with or without food, but it is better to take it at a fixed time. » Benefits « Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Nevimune Tablet may be taken with or without food, but it is better to take it at a fixed time. » common_side_effect « Headache | Vomiting | Nausea | Abdominal pain | Fatigue | Increased liver enzymes | Hepatitis (viral infection of liver) | Rash | Diarrhea » If_miss « . » Safety_advise « - Alcohol : CAUTION Caution is advised when consuming alcohol with Nevimune Tablet. Please consult your doctor. - Pregnancy : SAFE IF PRESCRIBED Nevimune Tablet is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies. - Breast feeding : SAFE IF PRESCRIBED Nevimune Tablet is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby. - Driving : UNSAFE Nevimune Tablet may cause side effects which could affect your ability to drive.You may experience fatigue while taking Nevimune Tablet and this may affect your ability to drive. - Kidney : SAFE IF PRESCRIBED Nevimune Tablet is safe to use in patients with kidney disease. No dose adjustment of Nevimune Tablet is recommended.However, inform your doctor if you have any underlying kidney disease. - Liver : CAUTION Nevimune Tablet should be used with caution in patients with liver disease. Dose adjustment of Nevimune Tablet may be needed. Please consult your doctor.Use of Nevimune Tablet is not recommended in patients with moderate to severe liver disease. Regular monitoring of liver function tests is advised while you are taking this medicine.

Manufacturers Cipla Ltd salt_composition Dicyclomine (10mg) + Paracetamol (40mg) » Prescription Required « Prescription Required In Treatment of Abdominal pain Spasmorid 10 mg/40 mg Drop effectively relieves sudden muscle spasms or contractions in the stomach and intestine (gut), thereby relaxing the muscles and improving the movement of food. It also blocks chemical messengers in the brain that are responsible for pain sensation. This helps to treat abdominal pain (or stomach pain) as well as cramps, bloating, and discomfort. Take Spasmorid 10 mg/40 mg Drop as prescribed to get maximum benefit. Eventually, it will help you to go about your daily activities more easily and have a more active and better quality of life. » how_to_use « Take this medicine in the dose and duration as advised by your doctor. Check the label for directions before use. Measure it with a marked dropper and take it as directed. Spasmorid 10 mg/40 mg Drop may be taken with or without food, but it is better to take it at a fixed time. » Benefits « Take this medicine in the dose and duration as advised by your doctor. Check the label for directions before use. Measure it with a marked dropper and take it as directed. Spasmorid 10 mg/40 mg Drop may be taken with or without food, but it is better to take it at a fixed time. » common_side_effect « Nausea | Dryness in mouth | Blurred vision | Sleepiness | Weakness | Nervousness » If_miss « If you miss a dose of Spasmorid 10 mg/40 mg Drop, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose. » Safety_advise « - Alcohol : UNSAFE It is unsafe to consume alcohol with Spasmorid 10 mg/40 mg Drop. - Pregnancy : SAFE IF PRESCRIBED Spasmorid 10 mg/40 mg Drop is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies. - Breast feeding : CONSULT YOUR DOCTOR Spasmorid 10 mg/40 mg Drop is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. - Driving : CONSULT YOUR DOCTOR It is not known whether Spasmorid 10 mg/40 mg Drop alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. - Kidney : CAUTION Spasmorid 10 mg/40 mg Drop should be used with caution in patients with kidney disease. Dose adjustment of Spasmorid 10 mg/40 mg Drop may be needed. Please consult your doctor. - Liver : CAUTION Spasmorid 10 mg/40 mg Drop should be used with caution in patients with liver disease. Dose adjustment of Spasmorid 10 mg/40 mg Drop may be needed. Please consult your doctor.However, the use of Spasmorid 10 mg/40 mg Drop is not recommended in patients with severe liver disease and active liver disease.

Manufacturers Cipla Ltd salt_composition Dicyclomine (20mg) + Paracetamol (500mg) » Prescription Required « Prescription Required In Treatment of Abdominal pain Spasmorid 20 mg/500 mg Tablet effectively relieves sudden muscle spasms or contractions in the stomach and intestine (gut), thereby relaxing the muscles and improving the movement of food. It also blocks chemical messengers in the brain that are responsible for pain sensation. This helps to treat abdominal pain (or stomach pain) as well as cramps, bloating, and discomfort. Take Spasmorid 20 mg/500 mg Tablet as prescribed to get maximum benefit. Eventually, it will help you to go about your daily activities more easily and have a more active and better quality of life. » how_to_use « Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Spasmorid 20 mg/500 mg Tablet may be taken with or without food, but it is better to take it at a fixed time. » Benefits « Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Spasmorid 20 mg/500 mg Tablet may be taken with or without food, but it is better to take it at a fixed time. » common_side_effect « Nausea | Dryness in mouth | Blurred vision | Sleepiness | Weakness | Nervousness » If_miss « If you miss a dose of Spasmorid 20 mg/500 mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose. » Safety_advise « - Alcohol : UNSAFE It is unsafe to consume alcohol with Spasmorid 20 mg/500 mg Tablet. - Pregnancy : SAFE IF PRESCRIBED Spasmorid 20 mg/500 mg Tablet is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies. - Breast feeding : CONSULT YOUR DOCTOR Spasmorid 20 mg/500 mg Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. - Driving : CONSULT YOUR DOCTOR It is not known whether Spasmorid 20 mg/500 mg Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. - Kidney : CAUTION Spasmorid 20 mg/500 mg Tablet should be used with caution in patients with kidney disease. Dose adjustment of Spasmorid 20 mg/500 mg Tablet may be needed. Please consult your doctor. - Liver : CAUTION Spasmorid 20 mg/500 mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Spasmorid 20 mg/500 mg Tablet may be needed. Please consult your doctor.However, the use of Spasmorid 20 mg/500 mg Tablet is not recommended in patients with severe liver disease and active liver disease.

Manufacturers Cipla Ltd salt_composition Sodium Cromoglycate (NA) » Prescription Required « Prescription Required In Treatment of Allergic eye disease Cromol Eye Drop helps relieve symptoms of allergic eye disease such as redness, swelling, itching and watering of eyes. This medicine works by decreasing the production of certain chemicals that cause inflammation of the eyes. This will make it easier for you to go about your daily activities. Use it as prescribed to get the most benefit. If you see no improvement even after a week, talk to your doctor. » how_to_use « This medicine is for external use only. Use it in the dose and duration as advised by your doctor. Check the label for directions before use. Hold the dropper close to the eye without touching it. Gently squeeze the dropper and place the medicine inside the lower eyelid. Wipe off the extra liquid. » Benefits « This medicine is for external use only. Use it in the dose and duration as advised by your doctor. Check the label for directions before use. Hold the dropper close to the eye without touching it. Gently squeeze the dropper and place the medicine inside the lower eyelid. Wipe off the extra liquid. » common_side_effect « Stinging sensation » If_miss « . » Safety_advise « - Alcohol : None No interaction found/established - Pregnancy : SAFE IF PRESCRIBED Cromol Eye Drop is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies. - Breast feeding : CONSULT YOUR DOCTOR Information regarding the use of Cromol Eye Drop during breastfeeding is not available. Please consult your doctor. - Driving : UNSAFE Cromol Eye Drop may cause blurring of your vision for a short time just after its use. Do not drive until your vision is clear.. - Kidney : None No interaction found/established - Liver : None No interaction found/established

Manufacturers Cipla Ltd salt_composition Glibenclamide (2.5mg) + Metformin (400mg) » Prescription Required « Prescription Required In Treatment of Type 2 diabetes mellitus Diaforte 2.5 mg/400 mg Tablet is a medicine that helps to control high blood glucose (sugar) levels. It helps get rid of extra glucose from your body through urine. It also improves the body’s response to the hormone insulin, which is responsible for regulating blood glucose (sugar) levels in our body. The insulin helps to lower your blood glucose levels and prevents them from rising after taking meals. You should keep taking it for as long as it is prescribed.\u003cbr>Lowering blood glucose levels is an essential part of managing diabetes. If you can control the level you will reduce the risk of getting any of the serious complications of diabetes such as kidney damage, eye damage, nerve problems, and loss of limbs. Taking this medicine regularly along with proper diet and exercise will help you live a normal, healthy life. » how_to_use « Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Diaforte 2.5 mg/400 mg Tablet is to be taken with food. » Benefits « Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Diaforte 2.5 mg/400 mg Tablet is to be taken with food. » common_side_effect « Nausea | Vomiting | Diarrhea | Flatulence » If_miss « If you miss a dose of Diaforte 2.5 mg/400 mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose. » Safety_advise « - Alcohol : UNSAFE It is unsafe to consume alcohol with Diaforte 2.5 mg/400 mg Tablet. - Pregnancy : SAFE IF PRESCRIBED Diaforte 2.5 mg/400 mg Tablet is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies. - Breast feeding : CAUTION Diaforte 2.5 mg/400 mg Tablet should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from her body. - Driving : CONSULT YOUR DOCTOR It is not known whether Diaforte 2.5 mg/400 mg Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. - Kidney : UNSAFE Diaforte 2.5 mg/400 mg Tablet is probably unsafe to use in patients with kidney disease and should be avoided. Please consult your doctor. - Liver : CAUTION Diaforte 2.5 mg/400 mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Diaforte 2.5 mg/400 mg Tablet may be needed. Please consult your doctor.Diaforte 2.5 mg/400 mg Tablet is generally started with low dose in patients with mild to moderate liver disease and its use is not recommended in patients with severe liver disease.

Manufacturers Cipla Ltd salt_composition Clobazam (10mg) » Prescription Required « Prescription Required In Treatment of Epilepsy/Seizures Zelip 10 Tablet slows down electrical signals in the brain that cause seizures (fits). It can also help reduce symptoms of seizures, such as confusion, uncontrollable jerking movements, loss of awareness, and fear or anxiety. This medicine can allow you to do some activities that you would otherwise be forbidden or scared to do (such as swimming and driving). It can take a few weeks for this medicine to work (because the dose has to be increased slowly) and during this time you may still have seizures. Therefore, do not stop using this medicine even if you feel well, until your doctor advises you to. Missing doses may trigger a seizure. » how_to_use « Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Zelip 10 Tablet may be taken with or without food, but it is better to take it at a fixed time. » Benefits « Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Zelip 10 Tablet may be taken with or without food, but it is better to take it at a fixed time. » common_side_effect « Constipation | Sleepiness | Depression | Dizziness | Dryness in mouth | Fatigue | Headache | Nausea | Sedation | Speech disorder | Decreased appetite | Irritability | Aggression | Restlessness | Drug tolerance | Difficulty in paying attention | Tremors | Abnormality of voluntary movements » If_miss « . » Safety_advise « - Alcohol : UNSAFE Zelip 10 Tablet may cause excessive drowsiness with alcohol. - Pregnancy : CONSULT YOUR DOCTOR Zelip 10 Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor. - Breast feeding : CONSULT YOUR DOCTOR Zelip 10 Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.Short-term use is not expected to cause any adverse effects in the breastfed baby, especially if the baby is older than 2 months. During long-term use, monitor for possible sleepiness. - Driving : UNSAFE Zelip 10 Tablet may cause side effects which could affect your ability to drive.You may feel sleepy or have concentration or memory problems after taking Zelip 10 Tablet and this may affect your ability to drive. - Kidney : CAUTION Zelip 10 Tablet should be used with caution in patients with kidney disease. Dose adjustment of Zelip 10 Tablet may be needed. Please consult your doctor.Limited information is available on the use of Zelip 10 Tablet in these patients. No dose adjustment is recommended in patients with mild to moderate kidney disease. - Liver : CAUTION Zelip 10 Tablet should be used with caution in patients with liver disease. Dose adjustment of Zelip 10 Tablet may be needed. Please consult your doctor.Limited information is available on use of Zelip 10 Tablet in patients with severe liver disease.

Manufacturers Cipla Ltd salt_composition Clobazam (5mg) » Prescription Required « Prescription Required In Treatment of Epilepsy/Seizures Zelip 5 Tablet slows down electrical signals in the brain that cause seizures (fits). It can also help reduce symptoms of seizures, such as confusion, uncontrollable jerking movements, loss of awareness, and fear or anxiety. This medicine can allow you to do some activities that you would otherwise be forbidden or scared to do (such as swimming and driving). It can take a few weeks for this medicine to work (because the dose has to be increased slowly) and during this time you may still have seizures. Therefore, do not stop using this medicine even if you feel well, until your doctor advises you to. Missing doses may trigger a seizure. » how_to_use « Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Zelip 5 Tablet may be taken with or without food, but it is better to take it at a fixed time. » Benefits « Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Zelip 5 Tablet may be taken with or without food, but it is better to take it at a fixed time. » common_side_effect « Constipation | Sleepiness | Depression | Dizziness | Dryness in mouth | Fatigue | Headache | Nausea | Sedation | Speech disorder | Decreased appetite | Irritability | Aggression | Restlessness | Drug tolerance | Difficulty in paying attention | Tremors | Abnormality of voluntary movements » If_miss « . » Safety_advise « - Alcohol : UNSAFE Zelip 5 Tablet may cause excessive drowsiness with alcohol. - Pregnancy : CONSULT YOUR DOCTOR Zelip 5 Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor. - Breast feeding : CONSULT YOUR DOCTOR Zelip 5 Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.Short-term use is not expected to cause any adverse effects in the breastfed baby, especially if the baby is older than 2 months. During long-term use, monitor for possible sleepiness. - Driving : UNSAFE Zelip 5 Tablet may cause side effects which could affect your ability to drive.You may feel sleepy or have concentration or memory problems after taking Zelip 5 Tablet and this may affect your ability to drive. - Kidney : CAUTION Zelip 5 Tablet should be used with caution in patients with kidney disease. Dose adjustment of Zelip 5 Tablet may be needed. Please consult your doctor.Limited information is available on the use of Zelip 5 Tablet in these patients. No dose adjustment is recommended in patients with mild to moderate kidney disease. - Liver : CAUTION Zelip 5 Tablet should be used with caution in patients with liver disease. Dose adjustment of Zelip 5 Tablet may be needed. Please consult your doctor.Limited information is available on use of Zelip 5 Tablet in patients with severe liver disease.